It seems several people still haven't heard about Crestone, so thought I'd make a quick mention of it here... The new Sitecore release (due out mid-year, hopefully) is code-named Crestone. The beta program is just spinning up, but a few details have leaked out already. 64-bit support is one of the big features. Also, in-line editing in web preview mode (I've seen this in other CMS's before and it's a huge selling point with customers), a new page layout tool, and a whole new security engine.
Yes, I'm going to apply for the beta program. If I'm accepted, I won't be able to blog about it for awhile though, unfortunately. As soon as I have more information to share though, I will!